Impaired synaptic pruning is associated with several neurodevelopmental disorders. Active microglial engulfment of synapses regulates brain development. However, the n-3 PUFAs deficiency-mediated mechanisms affecting the development of the central nervous system are poorly understood. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in Humans. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Nature Communications volume 11, Article number: 6133 ( 2020) Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain
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